In March, the world of drug testing was rocked by the unprecedented events at Northwick Park hospital in north London.
Six healthy men were given a drug that was being tested for the first time in humans.
Within hours they were suffering a drop in blood pressure, swellings, excruciating pain and were soon admitted to intensive care.
Graham Easton looks at the future of drug trials following the disastrous trials of TGN1412.
Will research into such sophisticated drugs be halted due to these adverse effects, or can we learn and adapt future drugs so that events like this never happen again?