In 1943, a Swiss scientist called Albert Hoffman was working on a substance called D-lysergic acid diethylamide that he'd first synthesized in his laboratory five years earlier.
It was then, that as he puts it, "I accidentally intoxicated myself." This moment was the first LSD 'trip': a drug that changed the scientist's state of mind, and was to go on to change everything from music to social mores when its use became widespread in the Sixties.
When he was on his 'trip' Albert Hoffman thought he was dying.
Sixty years on there are those who claim for LSD an unequalled insight into living.
In the programme, Doctor Susan Blackmore, the respected psychologist and broadcaster talks about her use of LSD in the early 1970s.
"I think LSD is the ultimate drug.
It reveals the world, the mind as it is.
I decided to get married on a trip.
We were in a forest and the trees came down to meet us and the leaves embraced us; it was magical."
The rock band Hawkwind used LSD throughout the1970s: they took it to write music, before they went onstage, as their record covers were designed.
It was the drug that led to the era of the rock concept album.
"Acid open's up the idea that music doesn't have to have conventional structures.
It enhances your hearing and changes the way you hear sounds.
We've replicated trips in our music and it liberated our work; we dispensed with the four minute pop song," explains Hawkwind's Dave Brock.
The programme features contributions from those who were there at the heart of the LSD explosion in Britain, a rare recording of Pink Floyd live at UFO, the first psychedelic club in London and we hear how LSD 'reincarnated' John Lennon